Research in FBM

The Fermentation Based Biomanufacturing initiative was founded in a research environment, which is world leading in both, synthetic biology and cell factory engineering as well as bioreactor engineering.
Four faculty positions will be established within the FBM Initiative, to complement the existing research with new working groups.

Bacterial Fermentation Physiology and Performance

Associate Professor Gerd M. Seibold
(DTU Bioengineering, Section Synthetic Biology)

Gerd Seibold

Gerd M. Seibold is a microbiologist interested in the identification and biochemical characterization of microbial transporters and metabolic pathways and their application for metabolic engineering of bacteria, mainly Corynebacterium glutamicum. His research is at the interface of microbial physiology and genetics, protein biochemistry, bioprocess engineering, and synthetic biology.
His research group "Bacterial Fermentation Physiology and Performance" works on the genetic engineering and optimization of microorganisms, investigates molecular mechanisms for signal transduction and stress responses and therefore develops and uses a collection of genetically encoded sensors. 

Gerd is teaching in the FBM Master studyline, where he is responsible for course Microbial Adaptation to Industrial Processes (27455). 



Fermentation Scale-up and Scale-down

Assistant Professor Helena Junicke
(DTU Chemical Engineering, PROSYS)

Helena Junicke
Dr. Helena Junicke is an expert for the design and analysis of sustainable bioprocesses. She is appointed Assistant Professor at the Process and Systems Engineering Centre (PROSYS), DTU Chemical Engineering, where she is driving research and teaching innovation within the Fermentation Based Biomanufacturing (FBM) program.
Helena holds a Biochemistry degree from Free University Berlin and a PhD in Environmental Biotechnology from Delft University of Technology. Her research combines applied fermentation studies and computational approaches to develop efficient bio-based production systems. Through her research, Helena seeks a deeper understanding of the fundamental working principles of microbial life and how it is controlled by the environmental conditions in industrial and natural settings.
Helena’s role in the FBM program encompasses research and teaching responsibilities. She is leading a research program in fermentation scale-up and scale-down, and has launched a research line on the production of biofuels and high-value chemicals from waste streams. In this context, she is exploring new sensor designs and big data technology to increase the robustness of industrial bioprocesses. Helena is study-line responsible for the Living Systems specialization on the Bachelor's program in General Engineering and contributes to diverse courses in the FBM study line (Biobusiness and Process Innovation- 28480; Biotechnology and process design - 28344; Advanced Topics in Process Technology - 28927).

Automation and High-Throughput (HTP) Micro Fermentation Technology

Assistant Professor Alessandra Procentese
DTU Bioengineering, Fermentation Core)

Alessandra Procentese

Alessandra has a degree in Industrial Biotechnology, and her interest is the conversion of waste into bioenergy and bio-chemicals through fermentation processes.
The goal of her research is to use the agro-food, urban and industrial waste disposal in innovative and environmental sustainable processes to convert them into new bio-products. In particular, her studies are focused on: biomass pretreatments (acid, alkaline, organosolv and biological pretreatments), kinetic characterization and optimization of enzymatic hydrolysis step, bacteria fermentation to produce bio-commodities. 
In the FBM educational programs, she is involved in teaching in the Master study line (Microbial Adaptation to Industrial Processes - 27455) and in the development of the MOOC “Fundamentals of Microbial Bioreaction Design”.


Fermentation Downstream Processing 

Professor Manuel Pinelo

(DTU Chemical Engineering, PROSYS)

Manuel Pinelo Manuel Pinelo is covering the FBM research area Downstream Processing. Manuel is a specialist in membrane technology, and in the framework of the  FBM-Initiative, he will expand his research to other unit operations.
He is focussing on two different types of activities:
1. Design and development of solutions for purification of fermentation products currently produced at Chemical Engineering (e.g. succinic acid), by combining current knowledge with novel techniques, resulting in new topologies or hybrid operations which can contribute to a more efficient, economically viable, and/or environmentally friendly production. The current examples of fermentation products will be taken as model examples for getting familiar and exploring the advantages of the new techniques and/or topologies.
2) Implementation and exploration of the potential of chromatography, liquid-liquid extraction, and other downstream unit operations. In this initial stage, it will be performed as a part of the purchasing process, by analyzing specifications of equipment and by inquiring about the needs that companies using such unit operations have. Innovation will be the key variable to consider in the process.

In terms of FBM teaching, Manuel is responsible for the courses 28434 - Membrane Technology and 28872 – Biorefinery, and he is contributing to 28233 - Recovery and purification of biological products, which are all mandatory or recommended courses for the FBM studyline.